Introduction -- Collocations, units of meaning and formulaic language -- Collocations and second language learning -- Methodology -- The first and second reflective cycles -- The third and fourth reflective cycles -- Discussion and conclusion.

Calpain (Cp) is a calcium (Ca2+)‐dependent cysteine protease. Activation of the major isoforms of Cp, CpI and CpII, are required for a number of important cellular processes including adherence, shape change and migration. The current concept that cytoplasmic Cp locates and associates with its regulatory subunit (Rs) and substrates as well as translocates throughout the cell via random diffusion is not compatible with the spatial and temporal constraints of cellular metabolism. The novel finding that Cp and Rs function relies upon (...) tenacious hydrophobic interactions with organelle membranes offers a unifying explanation for the paradoxical and puzzling features of Cp activation and regulation such as how nM concentrations of intracellular Ca2+ can activate Cp molecules requiring μM to mM concentrations of Ca2+ for in vitro activation, and how this protease can spatially and temporally locate specific substrates and translocate throughout the cell. We hypothesize that Cp and its regulatory moieties associate with organelles to facilitate the activation of this protease resulting in the cleavage of substrates and aid in its translocation throughout the cell. BioEssays 28: 850–859, 2006. © 2006 Wiley Periodicals, Inc. (shrink)

Numerous social, economic and academic pressures can have a negative impact on representations of biomedical research. We review several of the forces playing an increasingly pernicious role in how health and science information is interpreted, shared and used, drawing discussions towards the role of narrative. In turn, we explore how aspects of narrative are used in different social contexts and communication environments, and present creative responses that may help counter the negative trends. As traditional methods of communication have in many (...) ways failed the public, changes in approach are required, including the creative use of narratives. (shrink)

Normativni teoretičari pogreške nastoje braniti teoriju pogreške koja kaže da normativni sudovi pripisuju normativna svojstva, a takva svojstva, uključujući razloge za vjerovanje, nikada nisu instancirana. Mnogi filozofi su iznijeli prigovore obrani teorije koja podrazumijeva da ne možemo imati razloga vjerovati u nju. Spencer Case prigovara da teoretičari pogreške jednostavno ne mogu izbjeći samopobijanje. S druge strane, Bart Streumer tvrdi da ne možemo vjerovati u normativnu teoriju pogreške, ali da to, pomalo iznenađujuće, pomaže njenim zagovornicima da je obrane od ovih prigovora. (...) Smatram da, ako je Streumerov argument uspješan, on omogućuje teoretičarima pogreške izbjegavanje Caseovog prigovora o samopobijanju. Međutim, nadograđujem i poboljšavam Caseov argument kako bih pokazao da nikada ne bismo mogli uspješno obraniti normativnu teoriju pogreške, bez obzira na to možemo li vjerovati u nju ili ne. Dakle, samopobijanje ostaje. Rad zaključujem nudeći neke razloge za mišljenje da naša nesposobnost da obranimo normativnu teoriju pogreške znači da bismo je trebali odbaciti, što bi posljedično značilo da je ona neistinita. (shrink)

Soldiers hold special ethical obligations to prioritise care for those closest to them when dealing with combat casualties. This obligation draws on the unique, personal relationships already established, which soldiers have with their comrades. These relationships arguably overrule the need for impartiality barring only a significant difference in the severity of injuries. The bonds of fraternity deserve moral recognition that is not reflected in current conceptions of battlefield medical care. However, an ethics of care (or care ethics) approach does not (...) reject care for enemies but suggests that extension to them occurs when there is no significant difference in severity to comrades first. It also calls on a different form of care called ethical caring, which as opposed to natural caring requires introspection on behalf of the caregiver. Ethics of care distinguishes treatment of the enemy from emotionally detached positions. Emotional detachment rejects the call to care and denies the development of a relationship, which is a foundational principle of care ethics. (shrink)

Building on my previous exploration of the role of dance in the contemporary French political philosopher Jacques Rancière’s Aisthesis: Scenes from the Aesthetic Regime of Art, first published in French in 2011, the present essay turns to another book originally published in the same year, The Intervals of Cinema. Having previously established that the core of Rancière’s philosophical method is an analysis of philosophical homonyms into figurative dancing conceptual partners, I begin by applying that method to the first chapter of (...) Intervals, “Cinematic Vertigo: Hitchcock to Vertov and Back.” There I identify two series of such dancing partners, as follows: Hitchcock’s image-controlling, capitalist vertiginous fall, and Vertov’s movement-equalizing, communist balanced dance. I then critique the implicit marginalizing of women and female bodies in the films and chapter, including Hitchcock’s protagonist’s best friend and ex-fiancé, and Vertov’s cosmetologists and switchboard operators. Finally, I offer a corrective from the proto-feminist life of my grandmother, a onetime cosmetologist, switchboard operator, and Glamour Shots amateur model, my grandmother, Louise Nunnelley, or “Mamaw.” Such are the unacknowledged material basis of Rancière’s radical democratic philosophy, the specifically-embodied and positioned female dancers who continue to get lost in his figurative dance. (shrink)

This paper examines the role of ethics in addressing aspects of ecological restoration in culturally-saturated landscapes. Do we have the ethical tools to respond to the complex questions that restoration poses? We can see valued landscapes, such as the English Lake District, as culturally rich or as ecologically denuded. This paper will juxtapose the demands of retaining rich cultural narratives and those of rewilding (which would allow for greater self-sustaining biological diversity and space for unrestrained nature). Using the ethical theory (...) of responsive cohesion, this paper will explore the cultural narrative vs wildness question in the context of the English Lake District. (shrink)

Though Mathias Risse and Gabriel Wollner’s _On Trade Justice_ admirably incorporates the history of European philosophy and U.S. government, their otherwise reasonable proposals rest on dubious grounds. The book derives both much of its appeal, and its primary vulnerability, from a cluster of central terms that are situated precariously at the intersection of metaphors and concepts, or what Lakoff and Johnson call “metaphorical concepts.” In this article, I explore the three most important such terms, as featured in the following paraphrase (...) of theirs: “_Trade_ is an _embedded ground_ of justice.” For each italicized term, I conclude, Risse and Wollner vacil-late between its most conceptual and metaphorical meanings, thereby attempting to (a) stretch “trade” to identify prehistoric exchange with global capitalism, so as to (b) rebrand the contextual “ground” of this universal activity as a foundation, even though (c) foundations “embedded” in other foundations simply reduce to their lowest common denominator. The latter, in this case, is global capitalism, the most immoral practices of which they are thereby pressured to defend, including temporary forms of the very exploitation that they so persuasively reconceive and otherwise condemn. (shrink)

Kant talks about a transcendentally necessary mind and, less often, about an intelligible mind. The two characterizations of the mind have similarities. However, there are also important differences. The properties grouped under ‘transcendental’ are cognitive, those grouped under ‘intelligible’ are conative. The properties grouped under ‘transcendental’ are nearly all congenial to cognitive science. Many grouped under ‘intelligible are not.

Based upon an attentive reading of Nietzsche’s writings and his reception among post-Nietzschean thinkers, this book argues that Nietzsche’s philosophical enterprise constitutes a materialist metaphysics of pure becoming, of pure immanence and the power of the virtual.

In the Critique of Pure Reason (1781/7), Kant laid out a deep-running and largely original picture of the apperceptive mind, including a claim that in consciousness of self, one does not appear to oneself as an object and that consciousness of self is presupposed by consciousness of other things. As a result, consciousness of oneself does not provide knowledge of oneself and the referential apparatus of consciousness of self is radically different from other kinds of referential apparatus. The main purpose (...) of this paper is to summarize this picture and then explore how much of it is still to be found in his late, unfinished Opus Postumum (1800/04). (shrink)

A defence of the possibility of amoralism is important to discussions about the foundations of ethics and the justification of morality. I argue against Michael Smith's attempt to show, through a defence of internalism, that amoralism is incoherent. I argue first, that a de dicto reading of the externalist's explanation of changes in motivation which are pursuant upon changes in judgement is not objectionable or implausible as Smith contends; and second, that internalism cannot account for the effort of the will (...) required to make such changes in motivation. I also argue that the internalism/externalism debate can be diffused by considering the epistemic difficulties associated with identifying motivating states and by rejecting the notion that motivation can be understood in terms of psychlogical states. (shrink)

Through a number of examples of environmental interventions, this paper makes the claim that the unauthorised nature of some interventions is an integral part of their aesthetic quality. This does not mean that all such interventions have these qualities - only that the regulation of what can be done where and by whom could endanger the production of a rich seam of aesthetic experience, such as edginess and whimsy, and the aesthetic engagement of artists and the general public with places.

Substance has been a leading idea in the history of Western philosophy. _Joshua Hoffman and Gary S. Rosenkrantz_ explain the nature and existence of individual substances, including both living things and inanimate objects. Specifically written for students new to this important and often complex subject, _Substance_ provides both the historical and contemporary overview of the debate. Great Philosophers of the past, such as Aristotle, Descartes, Spinoza, Leibnitz, Locke, and Berkeley were profoundly interested in the concept of substance. And, the authors (...) argue, a belief in the existence of substances is an integral part of our everyday world view. But what constitutes substance? Was Aristotle right to suggest that artefacts like tables and ships don't really exist? _Substance: Its Nature and Existence_ is one of the first non-technical, accessible guides to this central problem and will be of great use to students of metaphysics and philosophy. (shrink)

It has been standard philosophical practice in analytic philosophy to employ intuitions generated in response to thought-experiments as evidence in the evaluation of philosophical claims. In part as a response to this practice, an exciting new movement—experimental philosophy—has recently emerged. This movement is unified behind both a common methodology and a common aim: the application of methods of experimental psychology to the study of the nature of intuitions. In this paper, we will introduce two different views concerning the relationship that (...) holds between experimental philosophy and the future of standard philosophical practice (what we call, the proper foundation view and the restrictionist view), discuss some of the more interesting and important results obtained by proponents of both views, and examine the pressure these results put on analytic philosophers to reform standard philosophical practice. We will also defend experimental philosophy from some recent objections, suggest future directions for work in experimental philosophy, and suggest what future lines of epistemological response might be available to those wishing to defend analytic epistemology from the challenges posed by experimental philosophy. (shrink)

In recent publications, there has been something of an emerging debate about the relationship between powers ontology and current accounts of time. It seems that if powers ontology is to have bearing on contemporary metaphysical accounts of time, some work needs to be done to show how powers ontology might overcome the apparent contradictions that have arisen in this emerging debate. One avenue to pursue is to test out the possibility of wresting a powers temporal ontology out of a re-reading (...) of Aristotle’s account of time with a specific focus on his account of motion and potency. This article will make an effort to make some headway here. (shrink)

Partiendo de mi exploración previa sobre el papel de la danza en la obra del filósofo político francés contemporáneo Jacques Rancière en su libro Aisthesis, publicado por primera vez en francés en 2011, el presente ensayo se centra en otro libro publicado originalmente en el mismo año, Las distancias del cine. Después de haber establecido previamente que el núcleo del método filosófico de Rancière implica un análisis de homónimos filosóficos en parejas conceptuales figurativas de baile, comienzo aplicando ese método al (...) primer capítulo de Distancias titulado “El vértigo cinematográfico: Hitchcock-Vertov y vuelta”. Allí identifico dos series de tales parejas de baile de la siguiente manera: la caída vertiginosa capitalista controlada por la imagen de Hitchcock y el baile equilibrado y comunista de Vertov que iguala los movimientos. Luego, critico la marginalización implícita de las mujeres y los cuerpos femeninos en las películas y el capítulo, incluyendo a la mejor amiga y ex prometida del protagonista de Hitchcock, así como a las cosmetólogas y operadoras de centralita de Vertov. Finalmente, ofrezco una corrección basada en la vida protofeminista de mi abuela, una vez cosmetóloga, operadora de centralita y modelo amateur de Glamour Shots, mi abuela Louise Nunnelley o “Mamaw”. Estos son la base material no reconocida de la filosofía democrática radical de Rancière, las bailarinas específicamente encarnadas y posicionadas que siguen perdiéndose en su baile figurativo. (shrink)

This article tests whether it is possible to be a ‘phenomenological-Thomist’ through the provision of the first stages of a loosely speaking Heideggerian phenomenological interpretation of the meaning of being an entity as it is disclosed in experience. In the process, the article will unpack and reinterpret the concepts of esse and esse commune in the thought of Thomas Aquinas.

In "How language helps us think", Jackendoff explores some of the relationships between language, consciousness, and thought, with a foray into attention and focus. In this paper, we will concentrate on his treatment of consciousness. We will examine three aspects of it: I. the method he uses to arrive at his views; 2. the extent to which he offers us a theory of consciousness adequate to assess his views; and 3. some of the things that we might need to add (...) to what he offers to achieve an adequate theory. (shrink)

Berkeley, Newton, Explanation, and Causation -/- I argue in this paper that Berkeley’s conception of natural law explanations, which echoes Newton’s, fails to solve a fundamental problem, which I label “explanatory asymmetry"; that the model of explanation Berkeley uses fails to distinguish between explanations and justifications, particularly since Berkeley denies real (efficient causes) in non-minded nature. At the end I suggest Berkeley might endorse a notion of understanding, say in astronomy or mechanics, which could be distinguished from explanation.

Advocates of the use of intuitions in philosophy argue that they are treated as evidence because they are evidential. Their opponents agree that they are treated as evidence, but argue that they should not be so used, since they are the wrong kinds of things. In contrast to both, we argue that, despite appearances, intuitions are not treated as evidence in philosophy whether or not they should be. Our positive account is that intuitions are a subclass of inclinations to believe. (...) Our thesis explains why intuitions play a role in persuasion and inquiry, without conceding that they are evidential. The account also makes predictions about the structure of intuitions that are confirmed by independent arguments. (shrink)

Recently, a number of theorists (MacFarlane (2003, 2011), Egan et al. (2005), Egan (2007), Stephenson (2007a,b)) have argued that an adequate semantics and pragmatics for epistemic modals calls for some technical notion of relativist truth and/or relativist content. Much of this work has relied on an empirical thesis about speaker judgments, namely that competent speakers tend to judge a present-tense bare epistemic possibility claim true only if the prejacent is compatible with their information. Relativists have in particular appealed to judgments (...) elicited in so-called eavesdropping and retraction cases to support this empirical thesis. But opposing theorists have denied the judgments, and at present there is no consensus in the literature about how the speaker judgments in fact pattern. Consequently there is little agreement on what exactly a semantics and pragmatics for epistemic modals should predict about the pattern of judgments in these cases. Further theorizing requires greater clarity on the data to be explained. To clarify the data, we subjected eavesdropping and retraction cases to experimental evaluation. Our data provide evidence against the claim that competent speakers tend to judge a present-tense bare epistemic possibility claim true only if the prejacent is compatible with their information. Theories designed to predict this result are accordingly undermined. (shrink)

This article provides an overview of controversies in the history of Chinese philosophy concerning the diversity of meanings of the term Li , as well as the comparative issues raised in various attempts by modern Chinese and Western interpreters to come to terms with this diversity of meanings. Revisiting the earliest pre-philosophical uses of the term, an attempt is then made to synthesize the insights of previous interpreters and open up a new path for investigating its distinctive implications in classical (...) Chinese thought, Chinese Buddhism, and Neo-Confucianism. (shrink)

One of the most influential methodological contributions of twentieth‐century philosophy was the approach known as conceptual analysis. The majority of experimental philosophy papers are doing cognitive science. They are revealing surprising new effects and then offering explanations those effects in terms of certain underlying cognitive processes. The best way to get a sense for actual research programs in experimental philosophy is to look in detail at one particular example. This chapter considers the effect of moral considerations on intuitions about intentional (...) action, as an example. Working in conceptual analysis aimed to develop analyses of concepts, and in that context, the obvious proposal would be that people should be aiming for simple analyses of concepts. The chapter also focuses on the study of intuitions about knowledge. Experimental philosophy has sought to capture the patterns in people's intuitions through theories about underlying cognitive processes. (shrink)

Our interest in this paper is to drive a wedge of contention between two different programs that fall under the umbrella of “experimental philosophy”. In particular, we argue that experimental philosophy’s “negative program” presents almost as significant a challenge to its “positive program” as it does to more traditional analytic philosophy.

This paper explores the Aristotelian context of the real distinction between existence and essence thought to be posited in Thomas Aquinas’ early workDe Ente Et Essentia. In doing so, the paper situates its own position in the context of contemporary scholarship and in relation to the contemporary trend to downplay Aristotle’s influence in Thomas Aquinas’ philosophy. The paper argues that re-readingDe Ente Et Essentiain this way sheds new light on some of the crucial debates in contemporary Thomist scholarship, particularly with (...) respect to the analogous relation between potency and act: essence and existence, the distinction between conceptual and causal explanation, and the relationship between philosophy and theology in the thought of Thomas Aquinas. (shrink)

Th e recent revival of Berkeley studies in the last three decades or so make it interesting to look back at George Santayana’s discussion of Berkeley. Th ough Santayana understood the latter’s arguments for immaterialism, he claimed no one could both seriously accept immaterialism, and live, as Berkeley certainly did, an embodied life. As he writes of Berkeley, “Th is idealist was no hermit” (205). Santayana claimed that without matter there was nothing (“no machinery”) for the soul to work on. (...) For a soul (mind) the machinery consists of material objects including one’s body. In this, paper, aft er some introductory comments, particularly on some aspects of early modern philosophy, e.g. the theory of ideas, which Berkeley largely accepts, and the metaphysics of indirect realism which he rejects, I look at the issue of human embodiment, and conclude, although Santayana perhaps misread important aspects of Berkeley’s discussion, he is largely correct in noting that Berkeley’s idealism/immaterialism can’t capture the special relation we have to our bodies. (shrink)

Abstract Tom Dougherty observes that challenges to counting the numbers often cite John Taurek’s 1977 article, “Should the Numbers Count.” Dougherty, though sympathetic to Taurek’s (and others) critique of consequentialism’s aggregating good across individuals, defends a non-consequentialist principle for addition he calls “the Ends Principle. Take the case (he labels “Drug”) when an agent, possessing a dose of a lifesaving drug, can save one person with the entire dose, or two people, each of whom only need half the dose. Dougherty (...) argues that a rational agent, summing her altruistic goals (three), but unable to save all three, will save two. I give two criticisms of Dougherty’s paper. (1) He hasn’t ruled out, though acknowledging, the equal chance principle as deontological grounds for deciding Drug. (2) An agent using the Ends Principle in Drug, as he formulates it, will not have the requisite aims to make use of the Principle. I also consider an issue, little discussed, the conditions for aggregation in general. (shrink)

Jennifer Nagel (2010) has recently proposed a fascinating account of the decreased tendency to attribute knowledge in conversational contexts in which unrealized possibilities of error have been mentioned. Her account appeals to epistemic egocentrism, or what is sometimes called the curse of knowledge, an egocentric bias to attribute our own mental states to other people (and sometimes our own future and past selves). Our aim in this paper is to investigate the empirical merits of Nagel’s hypothesis about the psychology involved (...) in knowledge attribution. (shrink)

Ideas adapted from the tradition of Chinese Tiantai Buddhism, in particular the notions of the "Three Truths" and "opening the provisional to reveal the real," are applied to the traditional mind-body problem as framed in Western philosophical discourse. An attempt is made to offer an account of the mind-body relation that explicates both the identity and the opposition between these two terms, thereby avoiding the traditional positions of dualism, monism, and parallelism while also accounting for the features of the relation (...) that have made these positions attractive in the past. (shrink)

All Mahayana schools adopt some version of the Two Truths theory, with one exception: the Tiantai school, which alone among all Buddhist schools moves from the Two Truths epistemology to a Three Truths model of truth. The Three Truths are actually three different ways of looking at any object or state. Each implies the other two, and each is one way to describe the whole of that object, including its other two aspects. This cup is a cup: that is provisional (...) truth, conventional truth, local coherence. This cup is not a cup: that is ultimate truth, its emptiness, its global incoherence. To be a cup is not to be a cup: that is its Centrality, its Non‐duality, its Absoluteness. This cup is all things, all possible ways of being, all universes, as this cup. (shrink)